Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 8/20 | 0.41 |
| ▸ | IGF1R | P08069 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525585 | 0.95 | MET (0.52) | METPOLBKDRIGF1RFLT3 | |
| SCHEMBL20525737 | 0.95 | MET (0.48) | METPOLBKDRIGF1RTDP1 | |
| SCHEMBL20525630 | 0.93 | MET (0.47) | METPOLBKDRIGF1RTDP1 | |
| SCHEMBL20525684 | 0.93 | MET (0.47) | METKDRTDP1FLT3 | |
| SCHEMBL20525574 | 0.92 | MET (0.47) | METPOLBKDRFLT3 | |
| SCHEMBL20525837 | 0.92 | MET (0.47) | METPOLBKDRTDP1FLT3 | |
| SCHEMBL20525690 | 0.92 | MET (0.48) | METPOLBKDRIGF1RTDP1 | |
| SCHEMBL20525829 | 0.91 | MET (0.47) | METPOLBKDRFLT3 | |
| SCHEMBL20525651 | 0.91 | MET (0.48) | METPOLBKDRTDP1FLT3 | |
| SCHEMBL20525522 | 0.91 | MET (0.51) | METPOLBKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |