Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525743 | 0.95 | MET (0.51) | METFLT3KDRAXL | |
| SCHEMBL20525793 | 0.93 | MET (0.50) | METFLT3KDR | |
| SCHEMBL20525840 | 0.92 | MET (0.49) | METFLT3KDR | |
| SCHEMBL20525853 | 0.92 | MET (0.48) | METFLT3KDRAXL | |
| SCHEMBL20525706 | 0.92 | MET (0.48) | METFLT3KDR | |
| SCHEMBL20525613 | 0.90 | MET (0.48) | METFLT3KDRAXL | |
| SCHEMBL20525585 | 0.90 | MET (0.52) | METFLT3KDRAXL | |
| SCHEMBL20525813 | 0.90 | MET (0.48) | METFLT3KDRAXL | |
| SCHEMBL20525627 | 0.90 | MET (0.48) | METFLT3KDRAXL | |
| SCHEMBL20525661 | 0.89 | MET (0.52) | METFLT3KDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |