Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525722 | 0.94 | MET (0.46) | METFLT3KDRAXL | |
| SCHEMBL20525822 | 0.94 | MET (0.47) | METFLT3KDRAXL | |
| SCHEMBL20525653 | 0.94 | MET (0.48) | METFLT3KDRAXL | |
| SCHEMBL20525650 | 0.93 | MET (0.49) | METFLT3KDRAXL | |
| SCHEMBL20525834 | 0.93 | MET (0.45) | METFLT3KDRAXL | |
| SCHEMBL20525622 | 0.93 | MET (0.45) | METFLT3KDRAXL | |
| SCHEMBL20525565 | 0.92 | MET (0.47) | METFLT3KDRAXL | |
| SCHEMBL20525693 | 0.92 | MET (0.48) | METFLT3KDRAXL | |
| SCHEMBL20525667 | 0.92 | MET (0.53) | METFLT3KDRAXL | |
| SCHEMBL20525701 | 0.92 | MET (0.49) | METFLT3KDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |