Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371680 | 0.96 | MET (0.67) | METKDRFLT3 | |
| SCHEMBL29693566 | 0.96 | MET (0.67) | METKDRFLT3 | |
| SCHEMBL29693580 | 0.92 | MET (0.68) | METKDRFLT3 | |
| SCHEMBL371608 | 0.92 | MET (0.68) | METKDRFLT3 | |
| SCHEMBL408201 | 0.91 | MET (0.66) | METKDRFLT3AXL | |
| SCHEMBL20525810 | 0.91 | MET (0.68) | METKDRFLT3AXL | |
| SCHEMBL407116 | 0.91 | MET (0.64) | METKDRFLT3AXL | |
| SCHEMBL372669 | 0.90 | MET (0.62) | METKDRFLT3AXL | |
| SCHEMBL371553 | 0.90 | MET (0.62) | METKDRFLT3AXL | |
| SCHEMBL371895 | 0.90 | MET (0.62) | METKDRFLT3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | disclosed |