SCHEMBL2052586

SCHEMBL2052586

O=C(O)c1cc(NC(=O)C2CCCC2)cc(C(=O)O)c1

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.62
LMNA P02545 1/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
HPGD P15428 1/20 0.59
HSD17B10 Q99714 1/20 0.58
ALDH1A1 P00352 1/20 0.56
PTPN1 P18031 1/20 0.54
KCNK3 O14649 1/20 0.54
KCNK9 Q9NPC2 1/20 0.54
GAA P10253 1/20 0.50
APEX1 P27695 1/20 0.50
IP6K1 Q92551 1/20 0.48
IP6K3 Q96PC2 1/20 0.48
IP6K2 Q9UHH9 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2052715 0.98 HPGD (0.62) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL11634580 0.89 NPSR1 (0.58) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL1948869 0.85 NPSR1 (0.75) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL11631579 0.83 HSD17B10 (0.55) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL11633045 0.83 NAMPT (0.52) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL1946708 0.83 NPSR1 (0.72) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL23070448 0.82 ALDH1A1 (0.78) NPSR1LMNAHPGDHSD17B10ALDH1A1
SCHEMBL1749350 0.82 PTPN1 (0.69) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL11732553 0.81 PTPN1 (0.72) NPSR1LMNAMEN1KMT2AHPGD
SCHEMBL694058 0.81 PTPN1 (0.72) NPSR1LMNAMEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2510047-A2 CLARIFIED POLYPROPYLENE ARTICLES WITH IMPROVED OPTICAL PROPERTIES AND/OR INCREASED TEMPERATURE OF CRYSTALLIZATION BASF SE (DE) 2012-10-17 EP disclosed
WO-2011071718-A2 CLARIFIED POLYPROPYLENE ARTICLES WITH IMPROVED OPTICAL PROPERTIES AND/OR INCREASED TEMPERATURE OF CRYSTALLIZATION BASF SE (DE) 2011-06-16 WO disclosed
EP-1592738-A2 RESIN COMPOSITIONS Ciba SC Holding AG (CH) 2005-11-09 EP disclosed
WO-2004072168-A2 RESIN COMPOSITIONS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-08-26 WO disclosed