Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206403 | 0.93 | MET (0.50) | METFLT3EGFRFGFR1FLT1 | |
| SCHEMBL3832618 | 0.93 | MET (0.52) | METFLT3EGFRFGFR1FLT1 | |
| SCHEMBL3227275 | 0.93 | MET (0.53) | METFLT3KDRIRAK4 | |
| SCHEMBL3835832 | 0.93 | MET (0.51) | METFLT3EGFRFGFR1FLT1 | |
| SCHEMBL3832583 | 0.93 | MET (0.57) | METFLT3KDRIRAK4 | |
| SCHEMBL15520757 | 0.93 | MET (0.52) | METFLT3EGFRFGFR1FLT1 | |
| SCHEMBL3836125 | 0.91 | MET (0.50) | METFLT3IRAK4 | |
| SCHEMBL15103894 | 0.91 | MET (0.54) | METFLT3KDRIRAK4 | |
| SCHEMBL4466096 | 0.90 | MET (0.51) | METFLT3IRAK4 | |
| SCHEMBL17867473 | 0.90 | MET (0.49) | METFLT3EGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | disclosed |