Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.71 |
| ▸ | GHSR | Q92847 | 16/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20528709 | 1.00 | CYP2D6 (0.71) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL24060790 | 0.93 | CYP2D6 (0.61) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL21686465 | 0.93 | CYP2D6 (0.77) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL20528748 | 0.88 | GHSR (0.58) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL20528750 | 0.88 | GHSR (0.58) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL24060800 | 0.86 | CYP2D6 (0.67) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL20528911 | 0.85 | CYP2D6 (0.74) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL20528914 | 0.85 | CYP2D6 (0.74) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL20528751 | 0.84 | GHSR (0.68) | CYP2D6GHSRKCNH2CYP3A4 | |
| SCHEMBL20528752 | 0.84 | GHSR (0.68) | CYP2D6GHSRKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2021-11-30 | — | — | US | disclosed |
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2021-11-30 | — | — | US | disclosed |
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2020-01-30 | — | — | US | disclosed |
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2020-01-30 | — | — | US | disclosed |
| WO-2018184115-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2018-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | TNNI3, KLK3, BRDT | CYP2D6 409/4885GHSR 1991/4885KCNH2 143/4885 |
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | TNNI3, KLK3, BRDT | CYP2D6 409/4885GHSR 1991/4885KCNH2 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.