Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631377 | 1.00 | NPC1 (0.49) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12632350 | 0.95 | ALDH1A1 (0.50) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12631025 | 0.93 | ALDH1A1 (0.53) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL2031255 | 0.93 | ALDH1A1 (0.53) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12632349 | 0.90 | NPC1 (0.58) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12631609 | 0.87 | NPC1 (0.52) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12631367 | 0.87 | ALDH1A1 (0.53) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL2038933 | 0.87 | ALDH1A1 (0.53) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12632369 | 0.86 | NPC1 (0.48) | NPC1ALDH1A1RAB9AKMT2AHTT | |
| SCHEMBL12631012 | 0.86 | ALDH1A1 (0.50) | NPC1ALDH1A1RAB9AKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | claimed |