Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22009108 | 1.00 | KDM4E (0.40) | KDM4ELMNASLC1A2CYP2C9CYP2C19 | |
| SCHEMBL22009120 | 1.00 | KDM4E (0.40) | KDM4ELMNASLC1A2CYP2C9CYP2C19 | |
| SCHEMBL22009110 | 1.00 | KDM4E (0.40) | KDM4ELMNASLC1A2CYP2C9CYP2C19 | |
| SCHEMBL22009191 | 1.00 | KDM4E (0.40) | KDM4ELMNASLC1A2CYP2C9CYP2C19 | |
| SCHEMBL22009109 | 1.00 | KDM4E (0.40) | KDM4ELMNASLC1A2CYP2C9CYP2C19 | |
| SCHEMBL14053439 | 0.80 | GRM5 (0.47) | KDM4ELMNASLC1A2CYP2C9CYP2C19 | |
| SCHEMBL22941781 | 0.73 | KDM4E (0.39) | KDM4ELMNAAPEX1EPHX2 | |
| SCHEMBL25946742 | 0.73 | KDM4E (0.39) | KDM4ELMNAAPEX1EPHX2 | |
| SCHEMBL3293689 | 0.73 | KDM4E (0.39) | KDM4ELMNAAPEX1MEN1KMT2A | |
| SCHEMBL10347490 | 0.73 | KDM4E (0.39) | KDM4ELMNAMEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287383-A1 | PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF | ENGENES BIOTECH GMBH (AT) | 2023-09-14 | — | — | US | disclosed |
| EP-4176050-A1 | PYRROLYSYL-TRNA SYNTHETASE VARIANTS AND USES THEREOF | enGenes Biotech GmbH (AT) | 2023-05-10 | — | — | EP | disclosed |
| WO-2022003142-A1 | PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF | ENGENES BIOTECH GMBH (AT) | 2022-01-06 | — | — | WO | disclosed |
| WO-2018185222-A1 | AMINOACYL TRNA SYNTHETASES AND ORTHOGONAL TRNAS | ACIB GMBH - AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY (AT) | 2018-10-11 | — | — | WO | disclosed |