Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.57 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.47 |
| ▸ | NOS2 | P35228 | 6/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 6/20 | 0.41 |
| ▸ | NOS3 | P29474 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22691090 | 0.95 | OTC (0.52) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL13445977 | 0.95 | OTC (0.52) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL13464207 | 0.95 | OTC (0.52) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL29286204 | 0.91 | OTC (0.45) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL29286205 | 0.91 | OTC (0.45) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL21611916 | 0.90 | OTC (0.48) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL21611915 | 0.90 | OTC (0.48) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL15618245 | 0.82 | OTC (0.51) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL15483719 | 0.81 | OTC (0.50) | OTCDDAH1NOS2CYP2C19CYP1A2 | |
| SCHEMBL17430453 | 0.80 | CA2 (0.39) | OTCDDAH1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287383-A1 | PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF | ENGENES BIOTECH GMBH (AT) | 2023-09-14 | — | — | US | claimed |
| EP-4176050-A1 | PYRROLYSYL-TRNA SYNTHETASE VARIANTS AND USES THEREOF | enGenes Biotech GmbH (AT) | 2023-05-10 | — | — | EP | claimed |
| WO-2022003142-A1 | PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF | ENGENES BIOTECH GMBH (AT) | 2022-01-06 | — | — | WO | claimed |
| WO-2018185222-A1 | AMINOACYL TRNA SYNTHETASES AND ORTHOGONAL TRNAS | ACIB GMBH - AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY (AT) | 2018-10-11 | — | — | WO | claimed |
| US-20230287383-A1 | PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF | ENGENES BIOTECH GMBH (AT) | 2023-09-14 | — | — | US | disclosed |
| EP-4176050-A1 | PYRROLYSYL-TRNA SYNTHETASE VARIANTS AND USES THEREOF | enGenes Biotech GmbH (AT) | 2023-05-10 | — | — | EP | disclosed |
| WO-2022003142-A1 | PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF | ENGENES BIOTECH GMBH (AT) | 2022-01-06 | — | — | WO | disclosed |
| WO-2018185222-A1 | AMINOACYL TRNA SYNTHETASES AND ORTHOGONAL TRNAS | ACIB GMBH - AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY (AT) | 2018-10-11 | — | — | WO | disclosed |