Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 10/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530315 | 0.91 | MET (0.40) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530357 | 0.89 | MEN1 (0.42) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530317 | 0.89 | MET (0.40) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530349 | 0.89 | MET (0.48) | ADORA2AADORA1METPKMCDKL5 | |
| SCHEMBL20530365 | 0.88 | ADORA2A (0.46) | ADORA2AADORA1MET | |
| SCHEMBL20530299 | 0.88 | MET (0.44) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530327 | 0.88 | MEN1 (0.38) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530350 | 0.88 | MEN1 (0.41) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530343 | 0.88 | BRAF (0.41) | MEN1NPC1RAB9AKMT2AADORA2A | |
| SCHEMBL20530348 | 0.88 | CNR1 (0.40) | MEN1NPC1RAB9AKMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |