Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803839 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AHSD17B10TDP1 | |
| SCHEMBL27750685 | 0.80 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AHSD17B10MTNR1A | |
| SCHEMBL2046625 | 0.79 | HTT (0.42) | HTTMEN1KMT2AHSD17B10MTNR1A | |
| SCHEMBL11484971 | 0.77 | HSD17B10 (0.52) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL2053129 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL2048346 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HTTMEN1KMT2AHSD17B10 | |
| SCHEMBL6423170 | 0.72 | ALDH1A1 (0.37) | ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL15624358 | 0.72 | KMT2A (0.55) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL6418597 | 0.68 | EPHX2 (0.35) | ALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL20131479 | 0.68 | SMN1; SMN2 (0.59) | ALDH1A1HTTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2329821-A1 | Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema | GlaxoSmithKline LLC (US) | 2011-06-08 | — | — | EP | disclosed |