Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2040973 | 0.86 | PDE10A (0.57) | PDE10A | |
| SCHEMBL2053605 | 0.82 | PDE10A (0.58) | PDE10A | |
| SCHEMBL2053912 | 0.78 | PDE10A (0.57) | PDE10AKDM4ENPC1RAB9A | |
| SCHEMBL2039411 | 0.78 | PDE10A (0.42) | PDE10A | |
| SCHEMBL2036380 | 0.76 | PDE10A (0.58) | PDE10AKDM4E | |
| SCHEMBL2037872 | 0.76 | PDE10A (0.48) | PDE10A | |
| SCHEMBL2034814 | 0.76 | PDE10A (0.57) | PDE10A | |
| SCHEMBL2038698 | 0.76 | PDE10A (0.50) | PDE10A | |
| SCHEMBL2044926 | 0.76 | PDE10A (0.59) | PDE10A | |
| SCHEMBL2043214 | 0.76 | PDE10A (0.50) | PDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072695-A1 | PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | claimed |