Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20533575 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1LMNATSHR | |
| SCHEMBL20533695 | 0.86 | PI4KB (0.42) | SMN1; SMN2ALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL20533748 | 0.86 | PI4KB (0.44) | SMN1; SMN2KDM4EALDH1A1LMNATSHR | |
| SCHEMBL20533660 | 0.85 | PI4KB (0.35) | SMN1; SMN2KDM4EALDH1A1LMNATSHR | |
| SCHEMBL20533905 | 0.83 | PI4KB (0.33) | NR1H2NR1H3 | |
| SCHEMBL20533914 | 0.83 | PI4KB (0.42) | SMN1; SMN2ALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL20533931 | 0.82 | RORC (0.37) | SMN1; SMN2KDM4EALDH1A1LMNATSHR | |
| SCHEMBL20533951 | 0.71 | HPGD (0.40) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL20533887 | 0.70 | PI4KB (0.47) | SMN1; SMN2KDM4EALDH1A1LMNATSHR | |
| SCHEMBL20533564 | 0.68 | GBA1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180298009-A1 | Fused Pyrazole Derivatives As Kinase Inhibitors | UCB BIOPHARMA SPRL (BE) | 2018-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180298009-A1 | Fused Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PI4K2B, PI4KB | SMN1; SMN2 4769/4885KDM4E 1098/4885ALDH1A1 3654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.