Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20533902 | 0.86 | KMT2A (0.56) | MAPTKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL20533944 | 0.85 | KMT2A (0.69) | MAPTKDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL20533770 | 0.83 | MAPT (0.55) | MAPTKDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL20534225 | 0.83 | KMT2A (0.53) | MAPTKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL20533949 | 0.83 | MAPT (0.73) | MAPTKDM4EHPGDNPSR1ALDH1A1 | |
| SCHEMBL20534226 | 0.83 | PI4KB (0.55) | MAPTKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL20533926 | 0.81 | MAPT (0.54) | MAPTKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL20533573 | 0.79 | MEN1 (0.49) | MAPTHPGDHSD17B10ALDH1A1KMT2A | |
| SCHEMBL20533577 | 0.71 | MTOR (0.46) | MAPTHPGDHSD17B10ALDH1A1KMT2A | |
| SCHEMBL5000710 | 0.69 | ALDH1A1 (0.54) | KDM4EHPGDHSD17B10NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180298009-A1 | Fused Pyrazole Derivatives As Kinase Inhibitors | UCB BIOPHARMA SPRL (BE) | 2018-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180298009-A1 | Fused Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PI4K2B, PI4KB | MAPT 2367/4885KDM4E 1098/4885HPGD 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.