Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535054 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDPTPN1 | |
| SCHEMBL20535441 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL20535434 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL13699672 | 0.88 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL20535680 | 0.88 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDPTPN1 | |
| SCHEMBL20534989 | 0.87 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDPTPN1 | |
| SCHEMBL20535050 | 0.87 | SMN1; SMN2 (0.49) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL20534963 | 0.83 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL20535051 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL20534970 | 0.83 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |