Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | HPGD | P15428 | 5/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3498056 | 0.88 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL1851374 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20534966 | 0.87 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20535680 | 0.87 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20535044 | 0.87 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20535965 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20535672 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20534973 | 0.82 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20535803 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20534817 | 0.82 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |