Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 3/20 | 0.40 |
| ▸ | CHUK | O15111 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852815 | 0.88 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20534824 | 0.87 | KDM4E (0.59) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535044 | 0.87 | KDM4E (0.61) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535680 | 0.87 | KDM4E (0.61) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535014 | 0.85 | KDM4E (0.78) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535672 | 0.85 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20534820 | 0.85 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20534973 | 0.82 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535803 | 0.82 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20534817 | 0.82 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |