Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR | P43088 | 3/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21632116 | 0.83 | PTGFR (0.46) | PTGFRTBXA2RRBP4ALDH1A1ESR1 | |
| SCHEMBL21631911 | 0.82 | PTGFR (0.40) | PTGFRTBXA2RRBP4ALDH1A1ESR1 | |
| SCHEMBL30838760 | 0.81 | KCNN4 (0.44) | TBXA2RRBP4ALDH1A1ESR1CYP3A4 | |
| SCHEMBL4826451 | 0.79 | ERCC5 (0.39) | TBXA2RNR3C1NR3C2ANO1 | |
| SCHEMBL20535152 | 0.78 | HTR2A (0.42) | PTGFRALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL5643833 | 0.73 | FFAR1 (0.43) | TBXA2RRBP4ALDH1A1ESR1CYP3A4 | |
| SCHEMBL803635 | 0.70 | PTGS1 (0.39) | NR3C1NR3C2CYP2C9HIF1A | |
| SCHEMBL5644509 | 0.70 | FFAR1 (0.40) | PTGFRTBXA2RRBP4ALDH1A1ESR1 | |
| SCHEMBL5427170 | 0.69 | FFAR1 (0.49) | TBXA2RALDH1A1CYP3A4MAPK1CYP2C9 | |
| Carbamic Acid SCHEMBL11788382 | 0.69 | HTR3E (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609869-A1 | SUBSTITUTED N-ARYLETHYL-2-ARYLQUINOLINE-4-CARBOXAMIDES AND USE THEREOF | Bayer Aktiengesellschaft (DE) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018189011-A1 | SUBSTITUTED N-ARYLETHYL-2-ARYLQUINOLINE-4-CARBOXAMIDES AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-10-18 | — | — | WO | disclosed |