⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535357 | 1.00 | — | — | |
| SCHEMBL20535776 | 0.86 | ICAM1 (0.31) | — | |
| SCHEMBL20535775 | 0.86 | ICAM1 (0.31) | — | |
| SCHEMBL20535990 | 0.84 | USP7 (0.32) | — | |
| SCHEMBL20535991 | 0.84 | USP7 (0.32) | — | |
| SCHEMBL20535591 | 0.82 | ITGAL (0.32) | — | |
| SCHEMBL20536400 | 0.81 | RHEB (0.34) | — | |
| SCHEMBL20536397 | 0.81 | RHEB (0.34) | — | |
| SCHEMBL20535493 | 0.81 | ALDH1A1 (0.39) | — | |
| SCHEMBL20535491 | 0.81 | ALDH1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |