Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | FUT4 | P22083 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535369 | 1.00 | LMNA (0.39) | LMNAKDM4EMAPK1HSD17B10CA12 | |
| SCHEMBL23294759 | 1.00 | LMNA (0.39) | LMNAKDM4EMAPK1HSD17B10CA12 | |
| SCHEMBL23316910 | 0.81 | KDM4E (0.46) | LMNAKDM4ECA12CA1CA2 | |
| SCHEMBL837173 | 0.80 | LMNA (0.33) | LMNAMAPTSMN1; SMN2KDM1ACYP1A2 | |
| SCHEMBL12246356 | 0.80 | LMNA (0.33) | LMNAMAPTSMN1; SMN2KDM1ACYP1A2 | |
| SCHEMBL837844 | 0.72 | LMNA (0.41) | LMNAALDH1A1TP53MAPTCA5A | |
| SCHEMBL10263865 | 0.72 | LMNA (0.41) | LMNAALDH1A1TP53MAPTCA5A | |
| SCHEMBL5053787 | 0.71 | LMNA (0.44) | LMNAKDM4EMAPK1HSD17B10CA12 | |
| SCHEMBL13304068 | 0.71 | LMNA (0.44) | LMNAKDM4EMAPK1HSD17B10CA12 | |
| SCHEMBL4129553 | 0.70 | LMNA (0.44) | LMNAKDM4EMAPK1HSD17B10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546140-B | Selective HDAC6 inhibitors | 意大发马克股份公司 | 2023-05-16 | — | — | CN | disclosed |
| EP-3562810-B1 | BENZHYDROXAMIC ACID DERIVATIVES AS SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-05-03 | — | — | EP | disclosed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
| CN-110546140-A | selective HDAC6 inhibitors | ITALFARMACO SPA | 2019-12-06 | — | — | CN | disclosed |
| EP-3562810-A1 | SELECTIVE HDAC6 INHIBITORS | Italfarmaco SpA (IT) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018189340-A1 | SELECTIVE HDAC6 INHIBITORS | ITALFARMACO S.P.A. (IT) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128577-A1 | Selective HDAC6 Inhibitors | HDAC6, HDAC1, HDAC3 | LMNA 4062/4885KDM4E 308/4885MAPK1 1776/4885 |
| US-11351178-B2 | Selective HDAC6 inhibitors | HDAC6, HDAC1, HDAC3 | LMNA 4000/4885KDM4E 304/4885MAPK1 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.