Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535680 | 0.87 | KDM4E (0.61) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20535044 | 0.87 | KDM4E (0.61) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20534824 | 0.85 | KDM4E (0.59) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20534966 | 0.85 | KDM4E (0.72) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20535057 | 0.85 | KDM4E (0.56) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL12660566 | 0.84 | KDM4E (0.69) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20534839 | 0.83 | KDM4E (0.57) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20534973 | 0.83 | KDM4E (0.60) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20535672 | 0.80 | KDM4E (0.60) | ALDH1A1HPGDKDM4EHSD17B10RAB9A | |
| SCHEMBL20535965 | 0.80 | KDM4E (0.60) | ALDH1A1HPGDKDM4EHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |