Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30772939 | 1.00 | PARP10 (0.50) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL25493443 | 0.84 | PARP10 (0.47) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL25492007 | 0.79 | SMN1; SMN2 (0.40) | PARP10PARP1KDM4EMEN1KMT2A | |
| SCHEMBL21760734 | 0.78 | MEN1 (0.60) | CA1CA2KDM4EMEN1KMT2A | |
| SCHEMBL4254063 | 0.77 | MAPT (0.49) | CA1CA2KDM4EMEN1KMT2A | |
| SCHEMBL20536528 | 0.76 | DYRK1A (0.60) | KDM4E | |
| SCHEMBL30772963 | 0.76 | DYRK1A (0.60) | KDM4E | |
| SCHEMBL14176085 | 0.74 | SSTR5 (0.49) | CA1CA2KDM4E | |
| SCHEMBL20536594 | 0.73 | ADH5 (0.52) | — | |
| SCHEMBL30772969 | 0.73 | ADH5 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609867-B1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSNO THERAPEUTICS INC (US) | 2024-05-15 | — | — | EP | disclosed |
| CN-110753683-B | Carbazole compounds and methods of use thereof | 吉斯诺治疗公司 | 2024-02-09 | — | — | CN | disclosed |
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSNO THERAPEUTICS, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSNO THERAPEUTICS, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSNO THERAPEUTICS, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-20200181129-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSNO THERAPEUTICS, INC. | 2020-06-11 | — | — | US | disclosed |
| US-20200181129-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSNO THERAPEUTICS, INC. | 2020-06-11 | — | — | US | disclosed |
| EP-3609867-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Saje Pharma, LLC (US) | 2020-02-19 | — | — | EP | disclosed |
| CN-110753683-A | Carbazole compounds and methods of use thereof | 赛吉制药有限责任公司 | 2020-02-04 | — | — | CN | disclosed |
| WO-2018191418-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | SAJE PHARMA, LLC (US) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSR, CBR3, CBR1 | PARP10 1367/4885CA1 2349/4885CA2 1468/4885 |
| US-20200181129-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSR, CBR3, CBR1 | PARP10 1367/4885CA1 2349/4885CA2 1468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.