Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20537306 | 0.94 | LRRK2 (0.49) | LRRK2JAK2ALK | |
| SCHEMBL20537463 | 0.94 | LRRK2 (0.49) | LRRK2JAK2ALK | |
| SCHEMBL17644582 | 0.94 | LRRK2 (0.55) | LRRK2JAK2EGFR | |
| SCHEMBL7455205 | 0.93 | LRRK2 (0.48) | LRRK2JAK2ALKULK1EGFR | |
| SCHEMBL20537315 | 0.93 | LRRK2 (0.48) | LRRK2JAK2ALKULK1EGFR | |
| SCHEMBL20537293 | 0.92 | LRRK2 (0.59) | LRRK2JAK2EGFR | |
| SCHEMBL20537296 | 0.92 | LRRK2 (0.58) | LRRK2JAK2ALKULK1EGFR | |
| SCHEMBL20537247 | 0.90 | LRRK2 (0.54) | LRRK2ALKEGFR | |
| SCHEMBL17644555 | 0.90 | LRRK2 (0.56) | LRRK2JAK2ALKULK1EGFR | |
| SCHEMBL20536978 | 0.86 | LRRK2 (0.53) | LRRK2ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3075730-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2018-10-24 | — | — | EP | claimed |