Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455205 | 0.94 | LRRK2 (0.48) | LRRK2ALKJAK2 | |
| SCHEMBL20537313 | 0.94 | LRRK2 (0.55) | LRRK2ALKJAK2 | |
| SCHEMBL20537463 | 0.90 | LRRK2 (0.49) | LRRK2ALKJAK2 | |
| SCHEMBL17644582 | 0.90 | LRRK2 (0.55) | LRRK2JAK2 | |
| SCHEMBL20537293 | 0.88 | LRRK2 (0.59) | LRRK2JAK2 | |
| SCHEMBL20537315 | 0.88 | LRRK2 (0.48) | LRRK2ALKJAK2 | |
| SCHEMBL20537441 | 0.87 | LRRK2 (0.57) | LRRK2ALK | |
| SCHEMBL20537296 | 0.86 | LRRK2 (0.58) | LRRK2ALKJAK2 | |
| SCHEMBL17644531 | 0.86 | LRRK2 (0.60) | LRRK2ALKJAK2 | |
| SCHEMBL20537247 | 0.85 | LRRK2 (0.54) | LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3075730-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2018-10-24 | — | — | EP | claimed |