Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16737487 | 0.78 | SYK (0.52) | SYKSRCZAP70CDK2 | |
| SCHEMBL2509056 | 0.78 | SYK (0.63) | SYKSRCZAP70 | |
| SCHEMBL16876267 | 0.71 | SYK (0.48) | SYK | |
| SCHEMBL16876174 | 0.71 | SYK (0.48) | SYK | |
| SCHEMBL16876381 | 0.71 | SYK (0.48) | SYK | |
| SCHEMBL16876558 | 0.70 | GRM8 (0.56) | SYKSRCZAP70CDK2 | |
| SCHEMBL16885381 | 0.70 | SYK (0.47) | SYK | |
| SCHEMBL2052608 | 0.69 | SYK (0.58) | SYK | |
| SCHEMBL16737670 | 0.69 | SYK (0.60) | SYK | |
| SCHEMBL16965340 | 0.69 | SYK (0.46) | SYKSRCZAP70CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |