SCHEMBL20538536

SCHEMBL20538536

CC(O)CNS(=O)(=O)c1ccccc1-c1ccc(-c2ncc(N)nc2C#N)c(F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 18/20 1.00
FEN1 P39748 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15916925 1.00 ALOX5AP (1.00) ALOX5APFEN1
SCHEMBL15915297 1.00 ALOX5AP (1.00) ALOX5APFEN1
SCHEMBL15917810 0.90 ALOX5AP (1.00) ALOX5APFEN1
SCHEMBL15916832 0.87 ALOX5AP (1.00) ALOX5APFEN1
SCHEMBL20538702 0.87 FEN1 (1.00) ALOX5APFEN1
SCHEMBL15917095 0.87 FEN1 (1.00) ALOX5APFEN1
SCHEMBL15917197 0.87 FEN1 (1.00) ALOX5APFEN1
SCHEMBL15917058 0.86 ALOX5AP (1.00) ALOX5APFEN1
SCHEMBL20538705 0.85 FEN1 (1.00) ALOX5APFEN1
SCHEMBL15932381 0.85 FEN1 (1.00) ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-10-24 EP claimed