SCHEMBL20538702

SCHEMBL20538702

CC(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2ncc(N)nc2C#N)c(F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 19/20 1.00
ALOX5AP P20292 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15917197 1.00 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15917095 1.00 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL21088712 0.91 FEN1 (0.82) FEN1ALOX5AP
SCHEMBL15916925 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15915297 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL20538536 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15917810 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15915779 0.86 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15916260 0.86 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL19272520 0.86 ALOX5AP (1.00) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-10-24 EP claimed