SCHEMBL20538692

SCHEMBL20538692

CC(NC(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 1.00
ALOX5AP P20292 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15916538 1.00 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916737 1.00 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916243 0.88 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15916884 0.88 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL20607599 0.88 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL20538671 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15916493 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15917014 0.87 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15924907 0.86 ALOX5AP (0.77) FEN1ALOX5AP
SCHEMBL15916426 0.86 ALOX5AP (0.77) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-10-24 EP claimed
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3070085-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 EP disclosed