Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16306645 | 0.85 | EPHX1 (0.56) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL13492972 | 0.84 | EPHX1 (0.55) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL20807875 | 0.82 | EPHX1 (0.61) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL22169803 | 0.82 | EPHX1 (0.54) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL3002292 | 0.82 | KDM4E (0.42) | EPHX1EPHX2CYP2D6KCNH2CACNA1I | |
| SCHEMBL16494745 | 0.81 | CYP2D6 (0.50) | EPHX1EPHX2CYP2D6HDAC4HDAC1 | |
| SCHEMBL22169792 | 0.81 | EPHX1 (0.52) | EPHX1EPHX2CYP2D6SMN1; SMN2KCNH2 | |
| SCHEMBL18134845 | 0.81 | EPHX1 (0.52) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL22302358 | 0.80 | EPHX1 (0.51) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL23523479 | 0.79 | CYP2D6 (0.49) | EPHX1EPHX2CYP2D6KCNH2CACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8623887-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-07 | — | — | US | disclosed |
| EP-2513110-A1 | 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073263-A1 | 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| US-20090163467-A1 | New compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163467-A1 | New compounds | CCNA1, MKI67, CCNT1 | EPHX1 721/4885EPHX2 2493/4885CYP2D6 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.