Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22306015 | 0.94 | EPHX1 (0.48) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL25089654 | 0.91 | EPHX1 (0.46) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL16771662 | 0.90 | TP53 (0.46) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I | |
| SCHEMBL25089651 | 0.84 | HSD11B1 (0.45) | EPHX1EPHX2KCNH2CACNA1IDPP4 | |
| SCHEMBL9891801 | 0.83 | MAPT (0.44) | EPHX1EPHX2DPP4PREPFAP | |
| SCHEMBL24865985 | 0.83 | EPHX1 (0.41) | EPHX1EPHX2KCNH2CACNA1IDPP4 | |
| SCHEMBL1107035 | 0.82 | TDP1 (0.52) | EPHX1EPHX2SMN1; SMN2DPP4PREP | |
| SCHEMBL23709475 | 0.81 | HTR4 (0.46) | EPHX1EPHX2KCNH2CACNA1IDPP4 | |
| SCHEMBL9891913 | 0.81 | EPHX2 (0.54) | EPHX1EPHX2SMN1; SMN2DPP4PREP | |
| SCHEMBL16306645 | 0.81 | EPHX1 (0.56) | EPHX1EPHX2SMN1; SMN2KCNH2CACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | BEIGENE, LTD. (KY) | 2022-01-11 | — | — | US | disclosed |
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | PIK3CD, PIK3R5, PIK3CA | EPHX1 4326/4885EPHX2 4316/4885SMN1; SMN2 3607/4885 |
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | PIK3CD, PIK3R5, PIK3CA | EPHX1 4326/4885EPHX2 4316/4885SMN1; SMN2 3607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.