Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2050433 | 0.80 | NCEH1 (0.41) | LMNAL3MBTL1CYP2A6NCEH1MAPT | |
| SCHEMBL31498466 | 0.74 | BDKRB2 (0.46) | TLR8LMNACYP2A6TP53CYP3A4 | |
| SCHEMBL4586831 | 0.73 | ESR1 (0.44) | TLR8LMNATP53CYP3A4SLC6A4 | |
| SCHEMBL2400221 | 0.72 | ESR1 (0.47) | TLR8LMNATP53CYP3A4SLC6A4 | |
| SCHEMBL2403161 | 0.72 | ESR1 (0.47) | TLR8LMNATP53CYP3A4SLC6A4 | |
| SCHEMBL9128028 | 0.72 | ESR1 (0.47) | TLR8LMNATP53CYP3A4SLC6A4 | |
| SCHEMBL27878175 | 0.70 | TYR (0.50) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL27827947 | 0.70 | TYR (0.50) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL5011027 | 0.69 | ESR1 (0.40) | TLR8LMNATP53CYP3A4SLC6A4 | |
| SCHEMBL29724725 | 0.69 | TLR8 (0.67) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331552-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010036551-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |