Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.51 |
| ▸ | NRAS | P01111 | 8/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15193708 | 0.87 | FLT3 (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15193705 | 0.87 | FLT3 (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15193755 | 0.85 | FLT3 (0.53) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL2054090 | 0.84 | NRAS (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL2054091 | 0.84 | NRAS (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15193360 | 0.84 | FLT3 (0.49) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15193357 | 0.84 | FLT3 (0.49) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15193514 | 0.83 | IRAK4 (0.58) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15193516 | 0.83 | IRAK4 (0.58) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL15194118 | 0.83 | IRAK4 (0.51) | FLT3IRAK4IRAK1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |