Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NRAS | P01111 | 10/20 | 0.51 |
| ▸ | FLT3 | P36888 | 14/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 3/20 | 0.51 |
| ▸ | CCNH | P51946 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054090 | 1.00 | NRAS (0.51) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL2054064 | 0.91 | FLT3 (0.47) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL2054065 | 0.91 | FLT3 (0.47) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL15193755 | 0.86 | FLT3 (0.53) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL2052907 | 0.86 | FLT3 (0.46) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL2052909 | 0.86 | FLT3 (0.46) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL15194118 | 0.86 | IRAK4 (0.51) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL15193072 | 0.86 | FLT3 (0.47) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL2054067 | 0.84 | FLT3 (0.51) | NRASFLT3IRAK4IRAK1PDGFRB | |
| SCHEMBL15193514 | 0.84 | IRAK4 (0.58) | NRASFLT3IRAK4IRAK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130216498-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2013-08-22 | — | — | US | disclosed |
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130216498-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK2, JAK3 | NRAS 486/4885FLT3 21/4885IRAK4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.