Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460400 | 0.79 | ALOX15 (0.53) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL11317872 | 0.74 | ALOX15 (0.60) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL11315039 | 0.72 | ALOX15 (0.67) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL3643589 | 0.71 | TP53 (0.55) | MAPTTP53POLBRXFP1 | |
| SCHEMBL14266744 | 0.71 | ALOX15 (0.69) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL4198671 | 0.71 | NPC1 (0.31) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL9597470 | 0.69 | ALOX15 (0.63) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL11319468 | 0.68 | ALOX15 (0.57) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL14256492 | 0.67 | ALOX15 (0.64) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL2930501 | 0.66 | GAA (0.56) | MAPTNPC1RAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163745-B2 | HIV inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-04-24 | — | — | US | disclosed |
| EP-2004641-B1 | HIV INHIBITING 5-(HYDROXYMETHYLENE AND AMINOMETHYLENE) SUBSTITUTED PYRIMIDINES | TIBOTEC PHARM LTD (IE) | 2010-09-29 | — | — | EP | disclosed |
| US-20100234375-A1 | HIV INHIBITING 5-(HYDROXYMETHYLENE AND AMINOMETHYLENE) SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2010-09-16 | — | — | US | disclosed |
| WO-2007113256-A1 | HIV INHIBITING 5-(HYDROXYMETHYLENE AND AMINOMETHYLENE) SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234375-A1 | HIV INHIBITING 5-(HYDROXYMETHYLENE AND AMINOMETHYLENE) SUBSTITUTED PYRIMIDINES | TYMS, TYMP, MTAP | MAPT 1784/4885NPC1 3051/4885RAB9A 2084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.