Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 20/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456662 | 0.99 | SCNN1A (0.54) | SCNN1A | |
| SCHEMBL16625864 | 0.93 | SCNN1A (0.46) | SCNN1A | |
| SCHEMBL16808735 | 0.92 | SCNN1A (0.54) | SCNN1A | |
| SCHEMBL13907673 | 0.92 | SCNN1A (0.54) | SCNN1A | |
| SCHEMBL9913772 | 0.92 | SCNN1A (0.64) | SCNN1A | |
| SCHEMBL10110642 | 0.91 | SCNN1A (0.49) | SCNN1A | |
| SCHEMBL12379741 | 0.91 | SCNN1A (0.53) | SCNN1A | |
| SCHEMBL10028705 | 0.91 | SCNN1A (0.65) | SCNN1A | |
| SCHEMBL9913777 | 0.91 | SCNN1A (0.57) | SCNN1A | |
| SCHEMBL9913768 | 0.91 | SCNN1A (0.65) | SCNN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878988-B2 | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases | PARION SCIENCES, INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-9856224-B2 | Stable sodium channel blockers | PARION SCIENCES, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20170267649-A1 | STABLE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170267649-A1 | STABLE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-9656972-B2 | Compounds for treatment of cystic fibrosis | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160159754-A1 | COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH | 2016-06-09 | — | — | US | disclosed |
| US-9260398-B2 | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases | PARION SCIENCES, INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150099764-A1 | DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES | PARION SCIENCES, INC. (US) | 2015-04-09 | — | — | US | disclosed |
| US-8980898-B2 | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases | PARION SCIENCES, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980898-B2 | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases | PARION SCIENCES, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-7745442-B2 | Methods of reducing risk of infection from pathogens | PARION SCIENCES, INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20090227530-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2009-09-10 | — | — | US | disclosed |
| US-20090062308-A1 | METHODS OF USING SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-7345044-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7332496-B2 | Broncholdilator agents; hydration of mucous membranes; respiratory system disorders | PARION SCIENCES, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332496-B2 | Broncholdilator agents; hydration of mucous membranes; respiratory system disorders | PARION SCIENCES, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070265280-A1 | METHODS OF USING SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2007-11-15 | — | — | US | disclosed |
| US-7247636-B2 | Phenolic guanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7241766-B2 | Methods of using phenolic guanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2007-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159754-A1 | COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS | CFTR, ELANE, OTC | SCNN1A 87/4885 |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885 |
| US-20150099764-A1 | DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES | SCNN1B, SCNN1A, SCNN1G | SCNN1A 2/4885 |
| US-20170267649-A1 | STABLE SODIUM CHANNEL BLOCKERS | SCN1B, SCN2B, CACNA1B | SCNN1A 25/4885 |
| US-20070265280-A1 | METHODS OF USING SODIUM CHANNEL BLOCKERS | SCN1B, KCNN3, SCN2B | SCNN1A 30/4885 |
| US-20090227530-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885 |
| US-20090062308-A1 | METHODS OF USING SODIUM CHANNEL BLOCKERS | SCN1B, KCNN3, SCN2B | SCNN1A 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.