SCHEMBL20544635

SCHEMBL20544635

CCc1cc(Cc2ccc(F)c(C(=O)N3CCn4c(-c5ccccc5)cnc4C3)c2)n[nH]c1=O

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 16/20 0.52
P2RX7 Q99572 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL4245999 0.96 PARP1 (0.52) PARP1P2RX7
SCHEMBL20544630 0.89 PARP1 (0.52) PARP1
Trifluoroacetic Acid SCHEMBL3984590 0.86 PARP1 (0.52) PARP1
SCHEMBL4541367 0.82 PARP1 (0.71) PARP1
SCHEMBL4246002 0.81 P2RX7 (0.45) PARP1P2RX7
SCHEMBL15988354 0.80 PARP1 (0.57) PARP1
SCHEMBL19005813 0.79 PARP1 (0.80) PARP1
Trifluoroacetic Acid SCHEMBL3063337 0.77 PARP1 (0.53) PARP1
SCHEMBL20544239 0.77 PARP1 (0.65) PARP1
SCHEMBL3551931 0.77 PARP1 (0.60) PARP1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029551-B1 PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) MSD ITALIA SRL (IT) 2018-10-31 EP claimed