Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.65 |
| ▸ | IGF1R | P08069 | 8/20 | 0.65 |
| ▸ | INSR | P06213 | 7/20 | 0.65 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.56 |
| ▸ | TTK | P33981 | 3/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | GAK | O14976 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 2/20 | 0.56 |
| ▸ | STK10 | O94804 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | FES | P07332 | 2/20 | 0.56 |
| ▸ | YES1 | P07947 | 2/20 | 0.56 |
| ▸ | HCK | P08631 | 2/20 | 0.56 |
| ▸ | ROS1 | P08922 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921184 | 0.95 | ALK (0.74) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19921063 | 0.91 | ALK (0.68) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19921081 | 0.88 | ALK (0.54) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19921104 | 0.87 | ALK (0.78) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19921155 | 0.86 | EGFR (0.74) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19867179 | 0.86 | ALK (0.70) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19921100 | 0.86 | ALK (0.52) | ALKIGF1RINSREGFRPTK2 | |
| SCHEMBL19921112 | 0.86 | PTK2 (0.62) | ALKIGF1RINSREGFRPTK2 | |
| SCHEMBL19921120 | 0.85 | ALK (0.70) | ALKIGF1RINSREGFRPTK2 | |
| SCHEMBL19921124 | 0.85 | ALK (0.56) | ALKIGF1RINSREGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | ALK 1505/4885IGF1R 4466/4885INSR 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.