Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 10/20 | 0.47 |
| ▸ | CDK9 | P50750 | 9/20 | 0.47 |
| ▸ | TTK | P33981 | 4/20 | 0.46 |
| ▸ | FES | P07332 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.42 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | INSRR | P14616 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LTK | P29376 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921093 | 0.91 | TTK (0.50) | CDK7CDK9TTKFESFLT3 | |
| SCHEMBL20546874 | 0.89 | TTK (0.43) | CDK7CDK9TTKPTK2ALK | |
| SCHEMBL20546166 | 0.83 | NPC1 (0.40) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL19921065 | 0.82 | PTK2 (0.40) | CDK7CDK9TTKFESFLT3 | |
| SCHEMBL19921078 | 0.80 | ALK (0.47) | CDK7CDK9TTKFESFLT3 | |
| SCHEMBL19921189 | 0.78 | TTK (0.39) | CDK7CDK9TTKFESFLT3 | |
| SCHEMBL20546930 | 0.78 | CDK7 (0.39) | CDK7CDK9TTKPTK2ALK | |
| SCHEMBL20547119 | 0.77 | EGFR (0.43) | PTK2ALKJAK2EGFRROS1 | |
| SCHEMBL19921173 | 0.76 | ALK (0.38) | CDK7CDK9ALKZAP70EGFR | |
| SCHEMBL20546931 | 0.75 | ALK (0.48) | PTK2ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | CDK7 437/4885CDK9 639/4885TTK 1018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.