Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 17/20 | 0.62 |
| ▸ | LATS2 | Q9NRM7 | 8/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29707469 | 0.87 | LATS1 (0.61) | LATS1LATS2EGFR | |
| SCHEMBL20547912 | 0.84 | LATS1 (0.61) | LATS1LATS2EGFR | |
| SCHEMBL20547760 | 0.76 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL29650587 | 0.73 | LATS1 (0.56) | LATS1LATS2EGFR | |
| SCHEMBL17142299 | 0.72 | CYP1A2 (0.45) | EGFR | |
| SCHEMBL3322882 | 0.71 | EGFR (0.56) | LATS1LATS2EGFRMKNK1MKNK2 | |
| SCHEMBL22302812 | 0.70 | LATS1 (0.56) | LATS1LATS2EGFR | |
| SCHEMBL31375184 | 0.70 | EGFR (0.53) | LATS1EGFRMKNK1MKNK2 | |
| SCHEMBL31375768 | 0.68 | EGFR (0.65) | LATS1EGFR | |
| SCHEMBL29650589 | 0.68 | EGFR (0.61) | LATS1LATS2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615537-A2 | 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS | Novartis AG (CH) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018198077-A2 | 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS | NOVARTIS AG (CH) | 2018-11-01 | — | — | WO | disclosed |