Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 9/20 | 0.56 |
| ▸ | LATS2 | Q9NRM7 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | CD38 | P28907 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31375142 | 0.84 | GALR3 (0.58) | LATS1LATS2EGFRGALR3NR2F2 | |
| SCHEMBL29650600 | 0.83 | LATS1 (0.61) | LATS1LATS2SMN1; SMN2LMNAHTT | |
| SCHEMBL3322882 | 0.77 | EGFR (0.56) | LATS1LATS2LMNAHTTEGFR | |
| SCHEMBL15889088 | 0.77 | GALR3 (0.71) | SMN1; SMN2LMNAHTTEGFRCD38 | |
| SCHEMBL30117681 | 0.77 | GALR3 (0.71) | SMN1; SMN2LMNAHTTEGFRCD38 | |
| SCHEMBL20547912 | 0.77 | LATS1 (0.61) | LATS1LATS2EGFR | |
| SCHEMBL22302812 | 0.77 | LATS1 (0.56) | LATS1LATS2SMN1; SMN2LMNAEGFR | |
| SCHEMBL29707469 | 0.76 | LATS1 (0.61) | LATS1LATS2EGFR | |
| SCHEMBL10267527 | 0.75 | LATS1 (0.67) | LATS1LATS2 | |
| SCHEMBL31375768 | 0.75 | EGFR (0.65) | LATS1LMNAEGFRCD38NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |