Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90B1 | P14625 | 11/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11909583 | 0.81 | HSP90AA1 (0.42) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL11904625 | 0.79 | HSP90AA1 (0.58) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL11904860 | 0.78 | HSP90AA1 (0.46) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL1669554 | 0.76 | HSP90AB1 (0.54) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL1669324 | 0.75 | HSP90AB1 (0.53) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL1670754 | 0.74 | ERBB2 (0.43) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL11908898 | 0.74 | HSP90AA1 (0.48) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL11908349 | 0.73 | HSP90AA1 (0.44) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL28461213 | 0.71 | HSP90B1 (0.45) | HSP90B1HSP90AA1HSP90AB1ERBB2TRAP1 | |
| SCHEMBL1670182 | 0.71 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111683658-A | Multi-protein complex inhibitor therapy for traumatic brain injury and sequelae thereof | 萨缪斯治疗股份有限公司 | 2020-09-18 | — | — | CN | disclosed |
| EP-3641751-A2 | EPICHAPEROME INHIBITOR THERAPY FOR TRAUMATIC BRAIN INJURY AND SEQUELAE THEREOF | Samus Therapeutics, Inc. (US) | 2020-04-29 | — | — | EP | disclosed |
| EP-3615008-A1 | HSP90 INHIBITOR ORAL FORMULATIONS AND RELATED METHODS | Samus Therapeutics, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018237211-A2 | EPICHAPEROME INHIBITOR THERAPY FOR TRAUMATIC BRAIN INJURY AND SEQUELAE THEREOF | SAMUS THERAPEUTICS, INC. (US) | 2018-12-27 | — | — | WO | disclosed |
| WO-2018200534-A1 | HSP90 INHIBITOR ORAL FORMULATIONS AND RELATED METHODS | SAMUS THERAPEUTICS, INC. (US) | 2018-11-01 | — | — | WO | disclosed |