SCHEMBL20548447

SCHEMBL20548447

CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)NS(=O)(=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 3/20 0.60
CTSS P25774 3/20 0.49
CTSK P43235 2/20 0.49
ALDH1A1 P00352 1/20 0.48
TSHR P16473 1/20 0.48
MMP13 P45452 3/20 0.48
CTSL P07711 1/20 0.46
CTSB P07858 1/20 0.46
MCL1 Q07820 2/20 0.45
MMP9 P14780 1/20 0.45
MMP8 P22894 1/20 0.45
ADAMTS4 O75173 1/20 0.45
PPARG P37231 3/20 0.45
PPARA Q07869 3/20 0.45
ACE P12821 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
LARS1 Q9P2J5 1/20 0.43
PPARD Q03181 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14471896 1.00 BCL2 (0.60) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL30483893 0.91 BCL2 (0.58) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL12213922 0.89 BCL2 (0.61) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL14471778 0.87 BCL2 (0.63) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL8611600 0.85 BCL2 (0.76) BCL2CTSSCTSKCTSLCTSB
SCHEMBL18019117 0.85 BCL2 (0.61) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL21494650 0.84 ALDH1A1 (0.56) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL21494647 0.84 ALDH1A1 (0.56) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL16822821 0.83 BCL2 (0.59) BCL2CTSSCTSKALDH1A1TSHR
SCHEMBL16822822 0.83 BCL2 (0.59) BCL2CTSSCTSKALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2546231-B1 ALKYLAMINE DERIVATIVE EA PHARMA CO LTD (JP) 2018-11-07 EP disclosed