Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30124975 | 0.89 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3LNPEPKAT6A | |
| SCHEMBL1337657 | 0.89 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3LNPEPKAT6A | |
| SCHEMBL2320394 | 0.87 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3LNPEPKAT6A | |
| SCHEMBL29735165 | 0.85 | SLC6A4 (0.63) | SLC6A2SLC6A4SLC6A3LNPEPPARP10 | |
| SCHEMBL1438129 | 0.85 | SLC6A4 (0.63) | SLC6A2SLC6A4SLC6A3LNPEPPARP10 | |
| SCHEMBL29711702 | 0.82 | SLC6A4 (0.67) | SLC6A2SLC6A4SLC6A3LNPEP | |
| SCHEMBL1416985 | 0.82 | SLC6A4 (0.67) | SLC6A2SLC6A4SLC6A3LNPEP | |
| SCHEMBL26637455 | 0.79 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3LNPEPKMT2A | |
| SCHEMBL26637453 | 0.79 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3LNPEPKMT2A | |
| SCHEMBL15637209 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566847-B1 | NOVEL IMMUNOMODULATOR AND ANTI INFLAMMATORY COMPOUNDS | ICOZEN THERAPEUTICS PVT LTD (IN) | 2018-11-07 | — | — | EP | disclosed |