Sugi Predict

Sugi Predict / Compounds / SCHEMBL1337657

SCHEMBL1337657

SCHEMBL1337657

Brc1cccc(OC2CCCC2)c1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ SLC6A2 P23975 4/20 0.63
▸ SLC6A4 P31645 4/20 0.63
▸ SLC6A3 Q01959 4/20 0.63
▸ LNPEP Q9UIQ6 1/20 0.46
▸ MAOB P27338 3/20 0.42
▸ KAT6A Q92794 1/20 0.41
▸ HRH1 P35367 1/20 0.40
▸ F2 P00734 1/20 0.39
▸ PLG P00747 1/20 0.39
▸ PLAU P00749 1/20 0.39
▸ PLAT P00750 1/20 0.39
▸ KLKB1 P03952 1/20 0.39
▸ PRSS1 P07477 1/20 0.39
▸ PDK2 Q15119 1/20 0.39
▸ NPY1R P25929 1/20 0.39
▸ NPY2R P49146 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30124975 1.00 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL2320394 0.98 SLC6A2 (0.61) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL29735165 0.96 SLC6A4 (0.63) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL1438129 0.96 SLC6A4 (0.63) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL1416985 0.92 SLC6A4 (0.67) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL29711702 0.92 SLC6A4 (0.67) SLC6A2SLC6A4SLC6A3LNPEPMAOB
Bicarbonate SCHEMBL20548533 0.89 SLC6A2 (0.52) SLC6A2SLC6A4SLC6A3LNPEPKAT6A
SCHEMBL19280088 0.84 SLC6A4 (0.58) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL19384261 0.84 SLC6A2 (0.58) SLC6A2SLC6A4SLC6A3LNPEPMAOB
SCHEMBL30748791 0.84 SLC6A2 (0.58) SLC6A2SLC6A4SLC6A3LNPEPMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179059-A1 ANTICANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-06-05 — — US disclosed
US-12162870-B2 Anticancer compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-12-10 — — US disclosed
CN-117794525-A Anticancer compounds 加利福尼亚大学董事会 2024-03-29 — — CN disclosed
CN-107567443-B Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-28 — — CN disclosed
CN-115925679-A Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-07 — — CN disclosed
EP-3239143-B1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEMICAL LTD (KR) 2023-03-22 — — EP disclosed
US-20230025178-A1 ANTICANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-01-26 — — US disclosed
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEM, LTD. (KR) 2022-05-05 — — US disclosed
US-11261186-B2 Biaryl derivative as GPR120 agonist LG CHEM. LTD. (KR) 2022-03-01 — — US disclosed
WO-2020257487-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2020-12-24 — — WO disclosed
US-20080096942-A1 Substituted Hydroxyethylamines ELAN PHARMACEUTICALS, INC. 2008-04-24 — — US disclosed
US-20080096942-A1 Substituted Hydroxyethylamines ELAN PHARMACEUTICALS, INC. 2008-04-24 — — US disclosed
US-7312360-B2 Substituted hydroxyethylamines ELAN PHARMACEUTICALS, INC. (US) 2007-12-25 — — US disclosed
US-7312360-B2 Substituted hydroxyethylamines ELAN PHARMACEUTICALS, INC. (US) 2007-12-25 — — US disclosed
WO-2003050073-A1 SUBSTITUTED HYDROXYETHYLAMINES ELAN PHARMACEUTICALS, INC. (US) 2003-06-19 — — WO disclosed
CN-1071309-C 1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients GROUNENTHAL GMBH (DE) 2001-09-19 — — CN disclosed
EP-0780369-B1 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents GRUENENTHAL GMBH (DE) 2000-01-19 — — EP disclosed
US-5801201-A 1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients GRUENENTHAL GMBH (DE) 1998-09-01 — — US disclosed
CN-1157815-A 1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients GRUENENTHAL GMBH (DE) 1997-08-27 — — CN disclosed
EP-0780369-A1 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents Grünenthal GmbH (DE) 1997-06-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179059-A1 ANTICANCER COMPOUNDS BET1, BRD4, BICRA SLC6A2 2389/4885SLC6A4 2831/4885SLC6A3 2581/4885
US-20230025178-A1 ANTICANCER COMPOUNDS BET1, BRD4, BICRA SLC6A2 2389/4885SLC6A4 2831/4885SLC6A3 2581/4885
US-20080096942-A1 Substituted Hydroxyethylamines BACE1, BACE2, MME SLC6A2 729/4885SLC6A4 1307/4885SLC6A3 1309/4885
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST GPR119, GLP1R, GIPR SLC6A2 4117/4885SLC6A4 4706/4885SLC6A3 4158/4885
US-11261186-B2 Biaryl derivative as GPR120 agonist GPR119, GPR88, FFAR1 SLC6A2 3261/4885SLC6A4 4010/4885SLC6A3 3965/4885
US-12162870-B2 Anticancer compounds BET1, BRD4, BICRA SLC6A2 2389/4885SLC6A4 2831/4885SLC6A3 2581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.