SCHEMBL20548845

SCHEMBL20548845

C=CC(=O)Nc1cc(Nc2cc(Nc3ccc(C(F)(F)F)c(Cl)c3)ncn2)c(OC)cc1N(C)CC(C)(C)N

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
EGFR P00533 12/20 0.46
ERBB3 P21860 1/20 0.44
DUS2 Q9NX74 1/20 0.44
FGFR1 P11362 7/20 0.43
FGFR2 P21802 1/20 0.43
FGFR3 P22607 1/20 0.43
EML4 Q9HC35 2/20 0.43
ALK Q9UM73 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20548863 0.94 EGFR (0.46) EGFRERBB3DUS2FGFR1FGFR2
SCHEMBL20548969 0.91 EGFR (0.54) EGFRERBB3DUS2EML4ALK
SCHEMBL20548909 0.91 EGFR (0.47) EGFRERBB3DUS2EML4ALK
SCHEMBL35210287 0.90 EGFR (0.58) EGFREML4ALK
SCHEMBL20548847 0.90 EGFR (0.58) EGFREML4ALK
SCHEMBL20548786 0.85 EGFR (0.48) EGFRFGFR1FGFR2FGFR3EML4
SCHEMBL20549061 0.84 EGFR (0.48) EGFRFGFR1FGFR2FGFR3EML4
SCHEMBL20548937 0.84 EGFR (0.49) EGFRERBB3DUS2EML4ALK
SCHEMBL20548738 0.84 EGFR (0.49) EGFREML4ALK
SCHEMBL20548864 0.84 EGFR (0.58) EGFREML4ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3398939-B1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2026-05-06 EP claimed
EP-3398939-A1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY Ancureall Pharmaceutical (Shanghai) Co., Ltd. (CN) 2018-11-07 EP claimed
EP-3398939-B1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2026-05-06 EP disclosed
EP-3398939-A1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY Ancureall Pharmaceutical (Shanghai) Co., Ltd. (CN) 2018-11-07 EP disclosed