Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL20549229 | 0.90 | KCNH2 (0.64) | KCNH2SCN5ACYP3A4AADAT | |
| SCHEMBL20549590 | 0.85 | KCNH2 (0.59) | KCNH2SCN5ACYP3A4AADAT | |
| SCHEMBL20549800 | 0.85 | KCNH2 (0.58) | KCNH2SCN5ACYP3A4 | |
| SCHEMBL20549569 | 0.79 | KCNH2 (0.69) | KCNH2SCN5ACYP3A4AADAT | |
| Hydrochloric Acid SCHEMBL20549405 | 0.79 | KCNH2 (0.62) | KCNH2SCN5ACYP3A4AADAT | |
| Hydrochloric Acid SCHEMBL20549816 | 0.79 | KCNH2 (0.68) | KCNH2SCN5ACYP3A4AADAT | |
| Formic Acid SCHEMBL20549799 | 0.75 | KCNH2 (0.67) | KCNH2SCN5ACYP3A4AADAT | |
| Hydrochloric Acid SCHEMBL20549818 | 0.75 | KCNH2 (0.70) | KCNH2SCN5ACYP3A4AADAT | |
| SCHEMBL20549410 | 0.75 | KCNH2 (0.83) | KCNH2SCN5ACYP3A4AADAT | |
| SCHEMBL20549439 | 0.74 | KCNH2 (0.69) | KCNH2SCN5ACYP3A4AADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | TOP1, TOP2A, TOP2B | KCNH2 2920/4885SCN5A 1467/4885CYP3A4 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.