Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20549265 | 0.90 | KCNH2 (0.52) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| Hydrochloric Acid SCHEMBL20549818 | 0.86 | KCNH2 (0.70) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| SCHEMBL20549439 | 0.86 | KCNH2 (0.69) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| SCHEMBL20549569 | 0.86 | KCNH2 (0.69) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| Trifluoroacetic Acid SCHEMBL20549274 | 0.85 | KCNH2 (0.65) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| Hydrochloric Acid SCHEMBL20549816 | 0.85 | KCNH2 (0.68) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| SCHEMBL20549421 | 0.84 | KCNH2 (0.67) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| SCHEMBL20549326 | 0.84 | KCNH2 (0.67) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| Trifluoroacetic Acid SCHEMBL20549519 | 0.84 | KCNH2 (0.68) | KCNH2SCN5AAADATKDM4ETUBB4A | |
| Trifluoroacetic Acid SCHEMBL20549531 | 0.84 | KCNH2 (0.76) | KCNH2SCN5AAADATKDM4ETUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2018-11-08 | — | — | US | disclosed |
| WO-2018203302-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | NOVARTIS AG (CH) | 2018-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | TOP1, TOP2A, TOP2B | KCNH2 2920/4885SCN5A 1467/4885AADAT 2848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.