Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 3/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20549526 | 0.86 | KCNH2 (0.75) | KCNH2SCN5AKDM4EKMT2AAADAT | |
| SCHEMBL20549410 | 0.85 | KCNH2 (0.83) | KCNH2SCN5ACYP3A4KDM4EKMT2A | |
| SCHEMBL20549966 | 0.84 | KCNH2 (1.00) | KCNH2SCN5ACYP3A4KDM4EKMT2A | |
| SCHEMBL20549945 | 0.84 | KCNH2 (0.73) | KCNH2SCN5AKDM4EKMT2AAADAT | |
| SCHEMBL20549586 | 0.84 | KCNH2 (0.73) | KCNH2SCN5AKDM4EKMT2AAADAT | |
| SCHEMBL20549576 | 0.84 | KCNH2 (0.73) | KCNH2SCN5AKDM4EKMT2AAADAT | |
| SCHEMBL20549895 | 0.84 | KCNH2 (0.72) | KCNH2SCN5ACYP3A4KDM4EKMT2A | |
| SCHEMBL20549897 | 0.84 | KCNH2 (0.72) | KCNH2SCN5ACYP3A4KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL20549549 | 0.84 | KCNH2 (0.72) | KCNH2SCN5AKDM4EKMT2AAADAT | |
| Hydrochloric Acid SCHEMBL20549528 | 0.84 | KCNH2 (0.72) | KCNH2SCN5ACYP3A4KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | TOP1, TOP2A, TOP2B | KCNH2 2920/4885SCN5A 1467/4885CYP3A4 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.