Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.50 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20549572 | 1.00 | KCNH2 (0.50) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| SCHEMBL20549196 | 0.93 | KCNH2 (0.52) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| SCHEMBL20549197 | 0.93 | KCNH2 (0.52) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| SCHEMBL20549480 | 0.86 | KCNH2 (0.58) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| SCHEMBL20549479 | 0.86 | KCNH2 (0.58) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| SCHEMBL20549836 | 0.86 | KCNH2 (0.53) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| SCHEMBL20549840 | 0.86 | KCNH2 (0.53) | KCNH2AADATSCN5ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL20549818 | 0.83 | KCNH2 (0.70) | KCNH2AADATSCN5ACYP3A4KDM4E | |
| SCHEMBL20549326 | 0.82 | KCNH2 (0.67) | KCNH2AADATSCN5ACYP3A4KDM4E | |
| SCHEMBL20549552 | 0.82 | KCNH2 (0.48) | KCNH2AADATSCN5AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180318311-A1 | TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS | TOP1, TOP2A, TOP2B | KCNH2 2920/4885AADAT 2848/4885SCN5A 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.